General information on drug use in pregnancy: analgesic drugs

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Paracetamol is the analgesic of choice in pregnancy. Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) should be avoided in late pregnancy. Aspirin will affect maternal platelet function and is associated with increased risk of prepartum and postpartum haemorrhage. Other NSAIDs could be expected to demonstrate these same effects. NSAIDs may also cause premature closure of the fetal ductus arteriosus and delay labour and birth. Women taking opioids chronically who become pregnant should let their obstetrician and their neonatologist know about the opioid use. They should probably be delivered in an appropriate tertiary hospital, where development in the neonate of a withdrawal syndrome will be prevented if possible, looked for, and managed as necessary. See also Use of antirheumatic drugs in pregnancy.